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Institutionernas kurser för doktorander


Kursplan för

KBT090 - Industrial biotechnology
Kursplanen fastställd 2012-02-21 av programansvarig (eller motsvarande)
Ägare: MPBIO
7,5 Poäng
Betygskala: TH - Fem, Fyra, Tre, Underkänt
Utbildningsnivå: Avancerad nivå
Huvudområde: Bioteknik, Kemiteknik
Institution: 21 - KEMI OCH KEMITEKNIK

Undervisningsspråk: Engelska
Sökbar för utbytesstudenter
Blockschema: B

Modul   Poängfördelning   Tentamensdatum
Lp1 Lp2 Lp3 Lp4 Sommarkurs Ej Lp
0107 Tentamen 7,5 hp Betygskala: TH   7,5 hp   03 Jun 2013 fm V,  20 Aug 2013 em V

I program

MPBIO BIOTECHNOLOGY, MSC PROGR, Årskurs 1 (obligatorisk)


Professor  Lisbeth Olsson
Docent  Carl Johan Franzén



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För kurser inom Chalmers utbildningsprogram gäller samma behörighetskrav som till de(t) program kursen ingår i.

Kursspecifika förkunskaper

Basic course in Applied microbiology, Bioreaction engineering, Bioprocess technology, Chemical reaction engineering, or similar. Basic biochemistry course.


The aims of the course are that the students should gain a quantitative understanding of different types of bioreactors and cultivation technologies, and obtain knowledge concerning the different demands on cultivation conditions and process control offered by various cell systems such as bacteria, yeast, filamentous fungi as well as higher eukaryotes. Another aim of the course is that students should develop engineering competences like working with models, working with complex, open-ended problems, and communicating scientific problems in written and oral form.

Lärandemål (efter fullgjord kurs ska studenten kunna)

  • Design common microbial cultivation techniques such as batch-, fed-batch and chemostat cultures

  • Make quantitative descriptions of growth and metabolic behaviour in various microbial cell cultivation systems using mathematical modeling and simulation in Matlab

  • Choose suitable cultivation techniques and cell systems for various manufacturing and research purposes and discuss the advantages and disadvantages of various possibilities

  • Design metabolically based control strategies for cultivation of different cell systems such as bacteria, yeast, filamentous fungi and higher eukaryotes.

  • Formulate and communicate a proposal for a biotechnological research or development project, including choice of model organism, cultivation techniques, and analytical techniques.

  • Show awareness of important industrial applications of microbiology
  • Innehåll

    The course contains the following parts:

  • Bioreactor design

  • Cultivation principles, modes of operation

  • Oxygen transfer

  • Monitoring and control strategies for industrial and laboratory biological processes

  • Micro scale to production scale

  • Growth kinetics and process dynamics

  • Microbial physiology and overflow metabolism

  • Organism diversity

  • Cell culture

  • Physiologically based process control strategies

  • Downstream processing

  • Mathematical modeling and simulation using Matlab

  • Organisation

    The course includes lectures, exercises and project work.

    About half of the lectures are given by invited lecturers from industry or other universities, to give an overview of the field of industrial biotechnology in the Nordic region.

    Projects are done in groups of two students. A proposal for a biotechnological research or development project should be written, including choice of model organism, cultivation techiques, and analytical techniques. Project proposals will be presented in seminars and in a written report.

    Exercises on mathematical modeling and simulation are done in a computer studio. Students work in pairs and use Excel or Matlab to calculate yields and rates from given data, and simulate batch, fed-batch and continuous cultures, including gas exchange rates. Depending on the aptitude of the students, the simulations may involve control of the stirring rate and the feed rate to optimise microbial production


    Hand-outs and scientific publications.

    Chapters 3 and 4 in:

    Stephanopoulos, Aristidou and Nielsen (1998), Metabolic engineering. Principles and methodologies. Academic Press, 1998.
    Available as E-book via the Chalmers library, Science Direct database.

    The course literature used in KMB040 and KKR090 may also be used as reference books:

    Ratledge C. and Kristiansen B. (eds.): Basic Biotechnology, Cambridge University press (2006)

    Nielsen J, Villadsen J, Lidén G (2003) Bioreaction Engeering Principles (second edition), Kluwer Academic / Plenum Publishers


    The final grade is balanced from the written final exam; the report and the oral presentation of the project proposal; and the written report on simulation exercises. Further details are given in the course PM.

    Sidansvarig Publicerad: må 13 jul 2020.