|FTF225 - Tissue engineering II
| Kursplanen fastställd 2009-02-24 av programansvarig (eller motsvarande)
|Betygskala: TH - Fem, Fyra, Tre, Underkänt
|Utbildningsnivå: Avancerad nivå
Huvudområde: Bioteknik, Teknisk fysik
Institution: 16 - FYSIK
Max 20 studenter
MPBIO BIOTECHNOLOGY, MSC PROGR, Årskurs 1 (obligatoriskt valbar)
MPBIO BIOTECHNOLOGY, MSC PROGR, Årskurs 2 (valbar)
MPBME BIOMEDICAL ENGINEERING, MSC PROGR, Årskurs 2 (valbar)
MPBME BIOMEDICAL ENGINEERING, MSC PROGR, Årskurs 1 (obligatoriskt valbar)
Bitr professor Julie Gold
Behörighet:För kurser inom Chalmers utbildningsprogram gäller samma behörighetskrav som till de(t) program kursen ingår i.
KPO065 Tissue Engineering I and UCM010 Inledande cell och molekylär biologi, or KBB032 Biochemistry and Molecular Biology, or equivalent university-level, introductory course in cell and/or molecular biology
The aim of this course is to provide students experience in working in groups on an experimental research project on a topic of relevance to tissue engineering. The project work begins in the preceeding course KPO065 Tissue engineering I and involves the design, execution and analysis of experiments and their results. An additional aim of the course is to provide specific knowledge on scientific and technical aspects of growing tissues and organs, as well as broader understanding of the challenges of producing , storing, delivering and using tissue engineered products, and their ethical and regulatory issues.
Lärandemål (efter fullgjord kurs ska studenten kunna)
Present and defend methods used and results obtained from laboratory experiments of growing tissue engineered constructs.
Define what is a stem cell, the different types of stem cells, and describe various approaches to derive stem cell lines.
Have a basic understanding of stem cell proliferation and differentiation processes.
Describe important tools for characterizing cell and tissue properties, and which properties are of interest to charactize.
Cite applications of gene transfer in tissue engineering. Describe several viral and non-viral approaches of gene transfer.
Describe a general first approach for bioreactor design
considerations and scale-up of cell culture. Understand the importance,
and dimensions, of the cellularity and geometry of the tissue
Describe methods to modify biomaterial surfaces on sub-cellular, cellular and supracellular length scales.
Understand the processes of wound healing, angiogenesis and the
immune response in the case of implantation/transplantation of tissue
engineered constructs. Be familiar with approaches to control immune
rejection and to achieve immunoisolation of tissue engineered
Be familiar with methods to preserve tissue engineered products.
Discuss key safety, ethical and regulatory issues around tissue engineered products.
Critically evaluate scientific publications in the tissue engineering field.
This course is the continuation course to Tissue Engineering I and covers the following topics:
Clinical Implementation of tissue engineering: Host integration
Cell and tissue properties
Characterization of growing tissues and cells,
Gene therapy and drug delivery
Tailoring of biomaterials for scaffold optimizationj
Producing TE products
Ethical issues with TE
Regulatory issues of TE products
The course will consist of lectures, article review sessions and
laboratory work. Laboratory work will be carried out within the group
projects, and will be dependent on the specific project topic. The
students will interact with scientists developing various tissues such
as cartilage, bone, neural tissues and blood vessels.
Bhatia and Palsson, Tissue engineering, 2004. Handouts of lecture notes and scientific articles.
Grades for the course will be based on article review sessions, the
group project oral and written presentations, and an individual grade
from group members.