|TIF125 - Biomaterials
| Kursplanen fastställd 2012-02-21 av programansvarig (eller motsvarande)
|Betygskala: TH - Fem, Fyra, Tre, Underkänt
|Utbildningsnivå: Avancerad nivå
Institution: 16 - FYSIK
Sökbar för utbytesstudenter
22 Okt 2012 em H,
14 Jan 2013 em V,
30 Aug 2013 em V
MPBIO BIOTECHNOLOGY, MSC PROGR, Årskurs 1 (obligatoriskt valbar)
MPBIO BIOTECHNOLOGY, MSC PROGR, Årskurs 2 (valbar)
MPBME BIOMEDICAL ENGINEERING, MSC PROGR, Årskurs 2 (valbar)
Bitr professor Julie Gold
Behörighet:För kurser inom Chalmers utbildningsprogram gäller samma behörighetskrav som till de(t) program kursen ingår i.
UCM010 Inledande cell och molekylär biologi, or KBB032 Biochemistry and Molecular Biology, or equivalent university-level, introductory course in cell and/or molecular biology
The aim of this course is for students to learn the mechanisms by which the human body reacts to a foreign material being in contact with, or implanted into, living tissues. An understanding of tissue reactions to biomaterials is necessary in order to design new materials, surface treatments or strategies for repairing, replacing or regenerating tissues and organs.
Lärandemål (efter fullgjord kurs ska studenten kunna)
Describe the key components of the tissue-material interface.
Describe key properties of surfaces, proteins and biological fluids that influence the nature of protein adsorption to surfaces.
Describe the major components of tissue, and how cells interact with their microenvironments, both in vivo and in vitro.
Describe main issues in blood-material interactions, including platelet activation, fibrin clot formation, and mechanisms to control blood coagulation processes.
Define main symptoms of, and key cell types involved in the inflammatory response. Describe the four lines of defence of the inflammatory system, and the connections between blood coagulation and inflammatory processes.
Discuss the significance of biomaterials related infections, which bacteria are involved, and approaches to treat and prevent their occurance.
Describe the innate versus the acquired immune systems, including key cell types and molecular events involved in each.
Describe the Classical versus the Alternative pathways of complement activation, and the links between the inflammatory process and the complement system.
Describe complement-mediated reactions to biomaterials and how they are regulated and can be controlled.
Compare the phases of normal wound healing of tissues with those of wound healing around implant materials.
Describe the events leading to fibrous capsule formation around implants and the key parameters influencing its formation.
Be familiar with the regulatory guidelines for marketing medical devices and recommended tests to evaluated biocompatibility of devices and their materials.
The course investigates interactions between the human body and implant
biomaterials and devices. Focus is on the tissue-material interface,
from molecular level events to selected biological and physiological
consequences of these events. All implantation of materials into the
body creates a wound, and the wound healing procsess occuring around
the implant is key in determining the bodies reaction to the foreign
material. Understanding how we can influence cellular responses to
materials by engineering the biomaterial surfaces is an important goal
for the development of improved medical devices as well as tissue
engineered products. Host reactions to biomaterials will be covered.
These include protein-surface interactions, cell-surface interactions,
blood-material interactions, blood coagulation, inflammatory response,
infection, immune response, complement activation, and the overall
stages and processes of wound healing. The concept of biocompatibility
and methods for biological testing of biomaterials will also be covered.
The course is organized into lectures, homework assignments,
homework sessions to discuss answers to the homework questions, group
project work and a site visit to a medical device clinic or
Biomaterials: The Intersection of Biology and
Materials Science, J.S. Temenoff, A.G. Mikos, Pearson Prentice Hall,
2008 (note that this textbook will also be used in the course TIF050
Materials in medicine, Quarter 2)
- An Introduction to Tissue-Biomaterial Interactions, KC Dee, DA Puleo, R Bizios, Wiley-Liss, 2002.
- Biomaterials Science. An Introduction to Materials in Medicine
(Ed. Ratner B, Hoffman AS, Schoen FJ, Lemons JE), Academic Press, 2nd
- Handouts in the form of lecture notes and scientific journal articles.
Written final exam, group project report and project presentation, and individual grades from the group work.