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Institutionernas kurser för doktorander

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Kursplan för

Läsår
KFK021 - Biophysical chemistry  
 
Kursplanen fastställd 2012-02-21 av programansvarig (eller motsvarande)
Ägare: MPBIO
7,5 Poäng
Betygskala: TH - Fem, Fyra, Tre, Underkänt
Utbildningsnivå: Avancerad nivå
Huvudområde: Bioteknik, Kemiteknik
Institution: 21 - KEMI OCH KEMITEKNIK


Undervisningsspråk: Engelska
Sökbar för utbytesstudenter
Blockschema: A

Modul   Poängfördelning   Tentamensdatum
Lp1 Lp2 Lp3 Lp4 Sommarkurs Ej Lp
0107 Tentamen 6,0 hp Betygskala: TH   6,0 hp   17 Dec 2012 em H,  Kontakta examinator   Kontakta examinator  
0207 Laboration 1,5 hp Betygskala: UG   1,5 hp    

I program

MPNAT NANOTECHNOLOGY, MSC PROGR, Årskurs 1 (obligatoriskt valbar)
MPBIO BIOTECHNOLOGY, MSC PROGR, Årskurs 2 (valbar)
MPBIO BIOTECHNOLOGY, MSC PROGR, Årskurs 1 (obligatoriskt valbar)

Examinator:

Docent  Fredrik Westerlund


Ersätter

KFK020   Biofysikalisk kemi

Kursutvärdering:

http://document.chalmers.se/doc/c7bd88fd-9a74-4f7f-a388-ddae2eff02c3


Behörighet:

För kurser inom Chalmers utbildningsprogram gäller samma behörighetskrav som till de(t) program kursen ingår i.

Kursspecifika förkunskaper

General knowledge in chemistry corresponding to Chemistry with Biochemistry (KOO041, general chemistry, 21 ECTS credits), Physical Chemistry Bt (KFK162, physical chemistry, 7.5 ECTS credits) or Physical Chemistry (KFK053, physical chemistry, 7.5 ECTS credits).

Syfte

The course should make the student acquainted with modern methods of biophysics and biophysical chemistry by applying them in practical exercises for solving problems regarding properties and mechanisms of bio-molecular systems. The course is an extension of general physical chemistry with focus on biological applications, suitable for those who want to later work in pharmaceutical industry or with biochemical, biotechnical or bio-medicinal research. Together with other courses in spectroscopy and analytical chemistry, surface and colloidal chemistry, organic synthesis, and molecular biology or microbiology, the course will provide a general platform for problem-solving in the bio-science area, but also useful in some nano-science, polymer-science and soft-matter science contexts.

Lärandemål (efter fullgjord kurs ska studenten kunna)

The student should after the course be able to perform analysis of biomolecular structure and dynamics in solution using a range of biophysical methods such as UV-Vis spectroscopy, circular dichroism (CD), linear dichroism (LD), fluorescence spectroscopy (including polarized methods), laser based transient spectroscopy, calorimetry, gel electrophoresis, kinetics analysis, fluorescence microscopy and even single molecule level experiments. These elements are important in various biomedical and biotechnical contexts (e.g. drug development). Most of the concepts of physical chemistry (thermodynamics, kinetics, optical spectroscopy, molecular recognition, structure & function of biomacromolecules, hydrodynamics etc) that the student should get acquainted with during the course are general and the methods therefore prepare the student for many different areas, e.g. material science, paper chemistry, etc.

Innehåll

By "Biophysical Chemistry" we mean the application of the concepts and tools of physical chemistry, i.e. in the form of models (thermodynamics, quantum mechanics) and analytical techniques (spectroscopy, hydrodynamics), to problems of biological significance. Biological systems are complex and their function is based on various macromolecules (nucleic acids, proteins, polysaccharides) and defined aggregates (lipid membranes), and on a wide variety of receptor-ligand interactions. A typical approach to understanding is therefore to characterize minimal model systems using biophysical methods and then add increasing levels of complexity. Since it is methods rather than problems that typify the field of Biophysical Chemistry, we introduce these by illustrating how they can be applied to problems concerning DNA. However, the principles are general and examples showing how the techniques are equally applicable to proteins are also dealt with.
Typical general questions that underlie the course content are: Which characteristics of DNA are relevant in order to understand biological function, and to allow development of new analytical techniques, biotechnical methods, and therapeutic strategies? How can we quantitatively characterize the properties of DNA and exploit them to get the result we want?

Organisation

Lectures, Tutorials and Project

Litteratur

Parts of the following four books:
P.W. Atkins & J. de Paula, PHYSICAL CHEMISTRY, 7th edition;
C.R Cantor & P.R.Schimmel, BIOPHYSICAL CHEMISTRY, Part II;
C.R Cantor & P.R. Schimmel,BIOPHYSICAL CHEMISTRY, Part III and
A. Rodger & B. Nordén, CIRCULAR DICHROISM & LINEAR DICHROISM

Examination

Written final examination and approved project course (written report + oral presentation).


Sidansvarig Publicerad: må 13 jul 2020.