Syllabus for |
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| KBB056 - Structural biochemistry |
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| Owner: TKBIA |
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5,0 Credits (ECTS 7,5) |
| Grading: TH - Five, Four, Three, Not passed |
| Level: D |
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Department: 21 - CHEMISTRY AND CHEMICAL ENGINEERING
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Teaching language: Swedish
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Credit distribution |
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Examination dates |
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Sp1 |
Sp2 |
Sp3 |
Sp4 |
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No Sp |
| 0105 |
Examination |
5,0 c |
Grading: TH |
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5,0 c
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Contact examiner, |
Contact examiner, |
Contact examiner |
In programs
TKMTL CHEMICAL ENGINEERING(FOR ENGINEERS WITH U.C.IN CHEMICAL ENG), Year 2 (elective)
TTFYA ENGINEERING PHYSICS, Year 4 (elective)
TKBIA BIOENGINEERING, Year 4 (elective)
TKMTA CHEMICAL ENGINEERING, Year 4 (elective)
TKEFA CHEMICAL ENGINEERING WITH ENGINEERING PHYSICS, Year 4 (elective)
Examiner:
Professor
Richard Neutze
Replaces
KBB055
Structural biochemistry
Eligibility:
For single subject courses within Chalmers programmes the same eligibility requirements apply, as to the programme(s) that the course is part of.
Course specific prerequisites
Anyone at fourth year within the Bt or K programmes at Chalmers will automatically be accepted. Students at fourth year in other programmes or at Gothenburg University will probably also be accepted, but must contact Richard Neutze in advance. The course will have a significant mathematical component.
Aim
This course aims to give an understanding of the major methods for structure determination of proteins. The course will cover X-ray crystallography and Nuclear Magnetic Resonance Spectroscopy in detail, & Electron Microscopy in less detail. The various tools needed to interpret structure etc. will also be covered.
Goal
See Aim.
Content
The course will consist of lectures and laboratory assignments. Lectures will run for two hours three times a week & will cover space groups; X-ray diffraction theory; NMR spectroscopy theory; Electron microscopy theory; and several examples of protein structures and methods. Inter-dispersed within the lecture course will be the occasional tutorial where specific problems will be worked through. Laboratory exercises will run for one afternoon over seven weeks and are compulsory. They will consist of X-ray crystallisation & data collection, model building & structure analysis, and NMR spectroscopy.
Literature
Lecture notes will be placed on the homepage http://www.csb.gu.se/neutze/structure/
A useful (but not compulsory) text is Principles of Protein X-ray Crystallography, Jan Drenth. A significant fraction of the X-ray diffraction theory will follow this book quite closely.
Examination
A written exam (80 %) plus tutorial & laboratory reports (20 %).