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Syllabus for

Academic year
KMB025 - Gene expression and cell models
 
Owner: BIMAS
3,0 Credits (ECTS 4,5)
Grading: TH - Five, Four, Three, Not passed
Level: C
Department: 11 - MATHEMATICAL SCIENCES


Teaching language: English

Course module   Credit distribution   Examination dates
Sp1 Sp2 Sp3 Sp4 No Sp
0100 Examination 3,0 c Grading: TH   3,0 c   Contact examiner

In programs

TKBIA BIOENGINEERING, Year 4 (elective)
BIMAS MSc PROGRAMME IN BIOINFORMATICS, Year 1 (compulsory)
TITEA INFORMATION ENGINEERING, Year 4 (elective)

Examiner:

Professor  Olle Nerman



Eligibility:

For single subject courses within Chalmers programmes the same eligibility requirements apply, as to the programme(s) that the course is part of.

Course specific prerequisites

UMF016 Sequence Information.

Aim

An important field in bioinformatics is the interpretation of experimental information and how such information is used in relation to models of biological processes. For instance, in recent years the microchip array technology has made possible the generation of gene expression data at a large scale. The interpretation of such data is a significant and non-trivial problem in bioinformatics. The course gives an introduction to the underlying biological problems and to the mathematical and computer tools available.
The course also presents mathematical models of biological processes, from simple systems with few macromolecular components to more complex systems at the cellular level.

Content

Analysis and technical aspects of gene expression data:


  • Transcriptomics and DNA microarrays
  • Proteomics - expression, modification, localisation and interactions
  • The interpretion of large scale data
  • Clustering algorithms

Modeling of cellular processes:


  • Protein complex formation.
  • Models of intermediary metabolism and metabolic control
  • Genetic networks and regulatory circuits
  • Stochastic mechanisms in gene expression.
  • Mathematical models of the cell cycle
  • Biochemical oscillations and cellular rhythms.
  • Models of evolution.

Literature

Various articles and other printed material will be handed out.

Examination

Exercises and written exam.


Page manager Published: Thu 03 Nov 2022.