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Syllabus for

Academic year
KBT160 - Advanced organic synthesis  
Avancerad organisk syntes
 
Syllabus adopted 2020-10-14 by Head of Programme (or corresponding)
Owner: MPMCN
7,5 Credits
Grading: TH - Pass with distinction (5), Pass with credit (4), Pass (3), Fail
Education cycle: Second-cycle
Major subject: Bioengineering, Chemical Engineering with Engineering Physics, Chemical Engineering
Department: 21 - CHEMISTRY AND CHEMICAL ENGINEERING

The course round is cancelled. For further questions, please contact the director of studies MPMCN: MATERIALS CHEMISTRY, MSC PROGR, contact information can be found here


Teaching language: English
Application code: 30123
Open for exchange students: Yes
Block schedule: C
Minimum participants: 8
Maximum participants: 15

Module   Credit distribution   Examination dates
Sp1 Sp2 Sp3 Sp4 Summer course No Sp
0108 Project 7,5c Grading: TH   7,5c    

In programs

MPNAT NANOTECHNOLOGY, MSC PROGR, Year 1 (elective)
MPMCN MATERIALS CHEMISTRY, MSC PROGR, Year 2 (compulsory elective)
MPMCN MATERIALS CHEMISTRY, MSC PROGR, Year 1 (compulsory elective)

Examiner:

Jerker Mårtensson

  Go to Course Homepage


Eligibility

General entry requirements for Master's level (second cycle)
Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.

Specific entry requirements

English 6 (or by other approved means with the equivalent proficiency level)
Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.

Course specific prerequisites

General knowledge in organic chemistry corresponding to the course Advanced organic chemistry (KBT036) or to level 3 (HE level) of any Master programme in chemistry or equivalent.

Aim

Complex molecules, such as drugs, polymers, detergents, and natural products, are an innate part of everyone's daily life. Whether in an academic or in an industrial environment, the assembly of such complex molecules from simple and readily available compounds plays an integral and indispensable role in its development. Advanced organic synthesis is a course which explores the challenges posed by the assembly processes, i.e. the syntheses, by which complex molecules are constructed. It aims to equip the student with the necessary tools for efficient planning of successful synthetic routs to new compounds with improved or new desirable properties. It aims to provide the student with a thorough knowledge and understanding of: retrosynthetic analysis, analysis of selectivity and stereochemical problems, functional group interconversion and protective group methodology, modern methods for carbon-carbon, and carbon-heteroatom bond formations.

Learning outcomes (after completion of the course the student should be able to)

* Apply a retrosynthetic approach to the design of efficient multi step routes to complex organic molecules.
* Identify potential selectivity issues, and suggest appropriate synthetic methods and protective groups to circumvent them.
* Evaluate the proposed routes with respect to the availability of suitable starting materials.
* Evaluate the proposed routes with respect to environmental and health aspects.
* Suggest and evaluate a large number of modern synthetic methods for functional group inteconversions, and for the formation of new carbon-carbon or carbon-heteroatom bonds.
* Retrieve information from the original literature about the underlying mechanisms and experimental conditions for the reactions applied in synthesis of complex molecules.
* Identify key steps in the synthetic routes and effectively communicate the rationales for the applied experimental procedures based on the underlying reaction mechanisms.

Content

  • Retrosynthetic analysis
  • Analysis of selectivity and stereochemical problems
  • Functional group interconversion and protective group methodology
  • Modern methods for carbon-carbon, and carbon-heteroatom bond formations.

Literature

Classics in Total Synthesis II: More Targets, Strategies and Methods, K. C. Nicolaou, and S. A. Snyder, WILEY-VCH, 2003

Supplementary Text(s): Organic Chemistry, J. Clayden, N. Greevs, S. Warren, and P. Wothers, Oxford University Press.

Examination including compulsory elements

Coursework hand-ins, in-class tests, and oral presentations.


Page manager Published: Mon 28 Nov 2016.