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Syllabus for

Academic year
TDA505 - Three-dimensional structure
 
Owner: BIMAS
4,0 Credits (ECTS 6)
Grading: TH - Five, Four, Three, Not passed
Level: C
Department: 37 - COMPUTER SCIENCE AND ENGINEERING


Teaching language: English

Course module   Credit distribution   Examination dates
Sp1 Sp2 Sp3 Sp4 No Sp
0103 Written and oral assignments 4,0 c Grading: TH   4,0 c    

In programs

BIMAS MSc PROGRAMME IN BIOINFORMATICS, Year 1 (compulsory)
TITEA INFORMATION ENGINEERING, Year 4 (elective)

Examiner:

Bitr professor  Graham Kemp


Replaces

KMB020   Three-dimensional structure


Eligibility:

For single subject courses within Chalmers programmes the same eligibility requirements apply, as to the programme(s) that the course is part of.

Course specific prerequisites

UMF010 Introduction to bioinformatics.

Aim

The aims of this course are:

- to introduce the principles of macromolecular structure determination by NMR and X-ray crystallography;
- to present some of the computational challenges in macromolecular structure determination, analysis and modelling.
- to introduce some articles from the scientific literature that are related areas covered in this course.

At the end of this course, students should:

- understand the principles of macromolecular structure determination by NMR and X-ray crystallography;
- understand some computational methods used in protein modelling, protein docking, and other areas of structural bioinformatics;
- have some experience with software packages that are used in parts of the protein structure determination and modelling processes;
- be able to read, interpret and critically assess some articles from the scientific literature in areas covered in this course.

Content

Experimental protein structure determination using nuclear magnetic resonance (NMR) and X-ray crystallography.
comparative protein modelling;
protein fold recognition;
ab initio protein structure prediction;
protein shape representation;
protein-ligand interactions and applications in drug design;
conformational analysis;
protein-protein docking.

Organisation

Lectures and practicals, including the use of molecular modelling software.
Homepage: http://www.cs.chalmers.se/~kemp/teaching/bioinformaticsIII/

Literature

Lecture handouts; web-based resources; selected research articles.

Examination

A series of individual assignments.


Page manager Published: Thu 03 Nov 2022.