Syllabus for |
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| TDA505 - Three-dimensional structure |
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| Owner: BIMAS |
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4,0 Credits (ECTS 6) |
| Grading: TH - Five, Four, Three, Not passed |
| Level: C |
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Department: 37 - COMPUTER SCIENCE AND ENGINEERING
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Teaching language: English
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Credit distribution |
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Examination dates |
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Sp1 |
Sp2 |
Sp3 |
Sp4 |
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No Sp |
| 0103 |
Written and oral assignments |
4,0 c |
Grading: TH |
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4,0 c
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In programs
BIMAS MSc PROGRAMME IN BIOINFORMATICS, Year 1 (compulsory)
TITEA INFORMATION ENGINEERING, Year 4 (elective)
Examiner:
Bitr professor
Graham Kemp
Replaces
KMB020
Three-dimensional structure
Eligibility:
For single subject courses within Chalmers programmes the same eligibility requirements apply, as to the programme(s) that the course is part of.
Course specific prerequisites
UMF010 Introduction to bioinformatics.
Aim
The aims of this course are:
- to introduce the principles of macromolecular structure determination by NMR and X-ray crystallography;
- to present some of the computational challenges in macromolecular structure determination, analysis and modelling.
- to introduce some articles from the scientific literature that are related areas covered in this course.
At the end of this course, students should:
- understand the principles of macromolecular structure determination by NMR and X-ray crystallography;
- understand some computational methods used in protein modelling, protein docking, and other areas of structural bioinformatics;
- have some experience with software packages that are used in parts of the protein structure determination and modelling processes;
- be able to read, interpret and critically assess some articles from the scientific literature in areas covered in this course.
Content
Experimental protein structure determination using nuclear magnetic resonance (NMR) and X-ray crystallography.
comparative protein modelling;
protein fold recognition;
ab initio protein structure prediction;
protein shape representation;
protein-ligand interactions and applications in drug design;
conformational analysis;
protein-protein docking.
Organisation
Lectures and practicals, including the use of molecular modelling software.
Homepage:
http://www.cs.chalmers.se/~kemp/teaching/bioinformaticsIII/
Literature
Lecture handouts; web-based resources; selected research articles.
Examination
A series of individual assignments.