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Syllabus for

Academic year
KPO065 - Tissue engineering  
Tissue engineering
 
Syllabus adopted 2019-02-12 by Head of Programme (or corresponding)
Owner: MPBIO
7,5 Credits
Grading: TH - Five, Four, Three, Fail
Education cycle: Second-cycle
Major subject: Bioengineering, Engineering Physics
Department: 21 - CHEMISTRY AND CHEMICAL ENGINEERING


Teaching language: English
Application code: 08113
Open for exchange students: Yes
Maximum participants: 40

Module   Credit distribution   Examination dates
Sp1 Sp2 Sp3 Sp4 Summer course No Sp
0104 Examination 7,5c Grading: TH   7,5c   17 Mar 2020 pm SB_MU   Contact examiner,  Contact examiner

In programs

MPBIO BIOTECHNOLOGY, MSC PROGR, Year 2 (elective)
MPBIO BIOTECHNOLOGY, MSC PROGR, Year 1 (compulsory elective)
MPBME BIOMEDICAL ENGINEERING, MSC PROGR, Year 1 (compulsory elective)
MPBME BIOMEDICAL ENGINEERING, MSC PROGR, Year 2 (elective)

Examiner:

Paul Gatenholm

  Go to Course Homepage


Eligibility:


In order to be eligible for a second cycle course the applicant needs to fulfil the general and specific entry requirements of the programme that owns the course. (If the second cycle course is owned by a first cycle programme, second cycle entry requirements apply.)
Exemption from the eligibility requirement: Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling these requirements.

Course specific prerequisites

Courses in chemical and biological engineering.

Aim

Although the lives of thousands of people are saved by reconstructive surgeons, many people are still waiting for organ donations. Reconstructive surgery became, in the last decade, a new discipline - tissue engineering with focus on the fabrication of living replacement parts for the body in the laboratory. Tissue engineering includes biology, chemistry, material science, engineering, immunology and transplantation. This course provides a general understanding of tissue growth and development and the tools and theoretical information needed to design tissues and organs.

Learning outcomes (after completion of the course the student should be able to)

  • Describe the principles of tissue engineering
  • Describe clinical applications of tissue engineered products in regenerative medicine
  • Define the importance of scaffold materials in tissue engineering with focus on surface-, mechanical- and biological properties
  • Describe different scaffold materials and define in what applications these materials can be applied
  • Describe several scaffold fabrication techniques such as electrospinning and solvent casting/particulate leaching
  • Describe different biofabrication methods of tissue with focus on additive manufacturing, and particularly, the 3D Bioprinting technology
  • Describe the early events that occur in tissue development, from the first division in the egg to the migration of cells to form the different germ layers
  • Describe the formation of different organs due to gene regulations and cell signaling
  • Describe the equipment used in cell culturing laboratory
  • Describe the basic components of the Extracellular Matrix (ECM) and its importance in tissue engineering
  • Describe the signaling process between cells and cell-ECM and its potential
    outcomes on cellular fate
  • Define the importance of bioreactors in tissue engineering
  • In theory, design a bioreactor and put emphasis on its requirements for
    cultivation of tissue engineered products
  • Define the ethical and regulatory aspects of tissue engineering in clinical
    applications
  • Develop a project within the field of tissue engineering which seeks to solve
    unmet clinical needs

Content

The following topics will be covered: Introduction Cell biology, the basis of growth and differentiation, growth factors, In vitro and in vivo control of tissue development, polymer scaffolds and biofabrication techniques, stem cells and their differentiation, bioreactors, ethical and regulatory aspects of tissue engineering, translation to clinic.

Organisation

The course consists of lectures, seminars, laboratory- and project work. Laboratory
work will include an introduction to sterile technique, cell seeding laboratory and
tissue biofabrication. In the group projects, students will prepare grant proposals for
tissue engineering of selected tissue/organs for unmet clinical needs. The written
proposal will be submitted and presented orally.

Literature

Tissue engineering; Clemens van Blitterswijk, Jan De Boer, 2:nd edition Academic Press 2014

 

Examination including compulsory elements

Laboratory exercises, project report and project presentation. Individual active participation is required in all group work. Grading will reflect the level of achievement of the whole group, with individual adjustment of grades from the group grade applied when relevant.


Page manager Published: Mon 28 Nov 2016.