Syllabus for |
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| BBT020 - Advanced analytical chemistry: metabolomics and proteomics |
| Avancerad bioanalytisk kemi: metabolomik och proteomik |
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| Syllabus adopted 2019-02-12 by Head of Programme (or corresponding) |
| Owner: MPBIO |
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7,5 Credits
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| Grading: TH - Pass with distinction (5), Pass with credit (4), Pass (3), Fail |
| Education cycle: Second-cycle |
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Major subject: Bioengineering
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Department: 28 - BIOLOGY AND BIOLOGICAL ENGINEERING
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Teaching language: English
Application code: 08137
Open for exchange students: Yes
Maximum participants: 30
| Module |
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Credit distribution |
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Examination dates |
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Sp1 |
Sp2 |
Sp3 |
Sp4 |
Summer course |
No Sp |
| 0117 |
Examination |
3,5 c |
Grading: TH |
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3,5 c
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01 Jun 2021 pm J, |
09 Oct 2020 pm J, |
24 Aug 2021 am J |
| 0217 |
Project |
4,0 c |
Grading: TH |
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4,0 c
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In programs
MPBIO BIOTECHNOLOGY, MSC PROGR, Year 2 (elective)
MPBIO BIOTECHNOLOGY, MSC PROGR, Year 1 (compulsory elective)
Examiner:
Rikard Landberg
Go to Course Homepage
Eligibility
General entry requirements for Master's level (second cycle)
Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.
Specific entry requirements
English 6 (or by other approved means with the equivalent proficiency level)
Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.
Course specific prerequisites
Students taking this course should have taken and passed the following course:
KAM021 Advanced analytical chemistry
Students who have not taken this course should have taken similar courses elsewhere, or have equivalent experience.
Aim
The aim of this course is to give an overview of metabolomics and proteomics, and how they can be applied to advance understanding of biology and biological effects.
Learning outcomes (after completion of the course the student should be able to)
- Design a metabolomics or proteomics experiment to help solve a biological question
- Critically evaluate the use of different methods for metabolomics and proteomics
- Critically assess different data analysis tools
- Understand integration of metabolomics and proteomics data with other types of data
Content
New analytical tools allow us to start embracing the complexity of biological systems and using this to understand how they work and can be manipulated. Among the foremost of these are metabolomics and proteomics methods to measure as many metabolites and proteins as possible. These methods can provide novel insight into how different metabolic reactions are connected and can be altered, and are frequently used in both academic and industrial research environments. Besides basic biological research, both techniques are widely used in food, nutrition and health research.
During this course, you will get a broad overview of what can be done with metabolomics and proteomics, and how this can be applied in practice. You will also get the opportunity to generate your own lab-based data, which will be the basis of practical work on data analysis and the course project.
The course contains the following main topics:
- Metabolomics using NMR and mass spectrometry
- Proteomics
- Advanced applications of proteomics (glycoproteomics, phosphoproteomics)
- Study design and sample preparation
- Applications of metabolomics and proteomics in industry
- Fluxomics
- Imaging mass spectrometry metabolomics
- Multivariate data analysis for metabolomics and proteomics
- Integrating and analysing metabolomics and proteomics data
Organisation
The course includes lectures, study visits, laboratory exercises
and a project.
Literature
There is no textbook for this course. Students will be provided with relevant literature and be expected to use available reputable resources on the internet.
Examination including compulsory elements
The course grade will be based on project work, a seminar, laboratory reports and a written exam.