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Graduate courses

Departments' graduate courses for PhD-students.

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Syllabus for

Academic year
TIF125 - Cell and tissue interactions with biomaterials  
Cell- och vävnadsinteraktion med biomaterial
 
Syllabus adopted 2017-02-09 by Head of Programme (or corresponding)
Owner: MPBIO
7,5 Credits
Grading: TH - Five, Four, Three, Fail
Education cycle: Second-cycle
Major subject: Bioengineering
Department: 16 - PHYSICS


Teaching language: English
Open for exchange students: Yes
Block schedule: C

Course module   Credit distribution   Examination dates
Sp1 Sp2 Sp3 Sp4 Summer course No Sp
0107 Examination 7,5c Grading: TH   7,5c   04 Jun 2019 am M   13 Oct 2018 am M   30 Aug 2019 pm M  

In programs

MPBIO BIOTECHNOLOGY, MSC PROGR, Year 2 (elective)
MPBIO BIOTECHNOLOGY, MSC PROGR, Year 1 (compulsory elective)
MPBME BIOMEDICAL ENGINEERING, MSC PROGR, Year 1 (compulsory elective)
MPBME BIOMEDICAL ENGINEERING, MSC PROGR, Year 2 (elective)

Examiner:

Julie Gold


Eligibility:


In order to be eligible for a second cycle course the applicant needs to fulfil the general and specific entry requirements of the programme that owns the course. (If the second cycle course is owned by a first cycle programme, second cycle entry requirements apply.)
Exemption from the eligibility requirement: Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling these requirements.

Course specific prerequisites

Introductory course in cell and/or molecular biology.

Aim

The aim of this course is for students to learn the mechanisms by which the human body reacts to a foreign material being in contact with, or implanted into, living tissues. The goal is to understand normal wound healing in the absence of a foreign material, and then how the presence of a material might influence the outcome of the wound healing response. An understanding of tissue reactions to biomaterials is necessary in order to design new materials, surface treatments or strategies for repairing, replacing or regenerating tissues and organs.

Learning outcomes (after completion of the course the student should be able to)

Describe the key components of the tissue-material interface.

Describe key properties of surfaces, proteins and biological fluids that influence the nature of protein adsorption to surfaces.

Describe the major components of tissue, and how cells interact with their microenvironments, both in vivo and in vitro.

Describe main issues in blood-material interactions, including platelet activation, fibrin clot formation, and mechanisms to control blood coagulation processes.

Define main symptoms of, and key cell types involved in the inflammatory response. Describe the four lines of defence of the inflammatory system, and the connections between blood coagulation and inflammatory processes.

Discuss the significance of biomaterials related infections, which bacteria are involved, and approaches to treat and prevent their occurance.

Describe the innate versus the acquired immune systems, including key cell types and molecular events involved in each.

Describe the Classical versus the Alternative pathways of complement activation, and the links between the inflammatory process and the complement system.

Describe complement-mediated reactions to biomaterials and how they are regulated and can be controlled.

Compare the phases of normal wound healing of tissues with those of wound healing around implant materials.

Describe the events leading to fibrous capsule formation around implants and the key parameters influencing its formation.

Be familiar with the regulatory guidelines for marketing medical devices and recommended tests to evaluate biocompatibility of devices and their materials.


 

Content

The course investigates interactions between the human body and implant biomaterials and devices. Focus is on the tissue-material interface, from molecular level events to selected biological and physiological consequences of these events. All implantation of materials into the body creates a wound, and the wound healing process occuring around the implant is key in determining the bodies reaction to the foreign material. Understanding how we can influence cellular responses to materials by engineering the biomaterial surfaces is an important goal for the development of improved medical devices as well as tissue engineered products. Host reactions to biomaterials will be covered. These include protein-surface interactions, cell-surface interactions, blood-material interactions, blood coagulation, inflammatory response, infection, immune response, complement activation, and the overall stages and processes of wound healing. The concept of biocompatibility and methods for biological testing of biomaterials will also be covered.

Organisation

The course is organized into lectures, article review sessions, a mock trial, and a site visit to a medical device company, medical clinic or biomaterials research laboratory.

Literature

Textbook for the course: Biomaterials Science. An Introduction to Materials in Medicine (Ed.
Ratner B, Hoffman AS, Schoen FJ, Lemons JE), Academic Press, 3rd
Edition, 2013 - ebook Chalmers Library.

Supplementary texts used as reference:



  1. An Introduction to Tissue-Biomaterial Interactions, KC Dee, DA Puleo, R Bizios, Wiley-Liss, 2002.
  2. Biomaterials: The Intersection of Biology and Materials Science, J.S. Temenoff, A.G. Mikos, Pearson Prentice Hall, 2008
  3. Handouts in the form of lecture notes and scientific journal articles.



Examination including compulsory elements

Written final exam, quiz, written and oral article reviews/sessions, demonstrated knowledge and understanding at mock trial. Active participation is required during the mock trial and preparation for the mock trial.


Published: Wed 26 Feb 2020.