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Graduate courses

Departments' graduate courses for PhD-students.

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Syllabus for

Academic year
FTF225 - Tissue engineering II
 
Syllabus adopted 2014-02-24 by Head of Programme (or corresponding)
Owner: MPBIO
7,5 Credits
Grading: TH - Five, Four, Three, Not passed
Education cycle: Second-cycle
Major subject: Bioengineering, Engineering Physics
Department: 16 - PHYSICS


Teaching language: English
Block schedule: A
Maximum participants: 20

Course module   Credit distribution   Examination dates
Sp1 Sp2 Sp3 Sp4 Summer course No Sp
0104 Project 7,5c Grading: TH   7,5c    

In programs

MPBIO BIOTECHNOLOGY, MSC PROGR, Year 1 (compulsory elective)
MPBIO BIOTECHNOLOGY, MSC PROGR, Year 2 (elective)
MPBME BIOMEDICAL ENGINEERING, MSC PROGR, Year 1 (compulsory elective)
MPBME BIOMEDICAL ENGINEERING, MSC PROGR, Year 2 (elective)

Examiner:

Bitr professor  Julie Gold



Eligibility:


In order to be eligible for a second cycle course the applicant needs to fulfil the general and specific entry requirements of the programme that owns the course. (If the second cycle course is owned by a first cycle programme, second cycle entry requirements apply.)
Exemption from the eligibility requirement: Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling these requirements.

Course specific prerequisites

The course Tissue Engineering I is required as well as introductory course in cell and/or molecular biology.

Aim

The aim of this course is to provide students experience in working in groups on an experimental research project on a topic of relevance to tissue engineering. The project work involves the design, execution and analysis of experiments and their results. An additional aim of the course is to provide specific knowledge on scientific and technical aspects of growing tissues and organs, as well as broader understanding of the challenges of producing , storing, delivering and using tissue engineered products, and their ethical and regulatory issues.

Learning outcomes (after completion of the course the student should be able to)

Present and defend methods used and results obtained from laboratory experiments of growing tissue engineered constructs.


Define what is a stem cell, the different types of stem cells, and describe various approaches to derive stem cell lines.


Have an understanding of stem cell proliferation and differentiation processes, including the major signal transduction pathways.


Describe important tools for characterizing cell and tissue properties, and which properties are of interest to characterize.

Understand the importance of, dimensions,  the cellularity and geometry of , tissue microenvironments.


Describe methods to modify biomaterial surfaces on sub-cellular, cellular and supracellular length scales.


Understand the processes of wound healing, angiogenesis and the immune response in the case of implantation/transplantation of tissue engineered constructs. Be familiar with approaches to control immune rejection and to achieve immunoisolation of tissue engineered constructs.


Be familiar with methods to preserve tissue engineered products.


Discuss key safety, ethical and regulatory issues around tissue engineered products.

Be familiar with several clinical and industrial applications of tissue engineering.


Critically evaluate scientific publications in the tissue engineering field.

Content

This course is the continuation course to Tissue Engineering I and covers the following topics:
Clinical Implementation of tissue engineering: Host integration
Cell and tissue properties
Characterization of growing tissues and cells,
Gene therapy and drug delivery,
Stem cells,
Tailoring of biomaterials for scaffold optimization,
Microfluidic systems for generating and defining cell microenvironments,
Producing TE products,
Ethical issues with TE,
Regulatory issues of TE products

Organisation

The course will consist of lectures, article review sessions, laboratory work, oral exam, and site visit to clinical regenerative medicine laboratories. Small quizes throughout the course will aid in assessing student's learning progress. Laboratory work will be carried out within the group projects, and will be dependent on the specific project topic. The students will interact with scientists developing various tissues or tissue models, such as cartilage, liver, skin,  and blood vessels.

Literature

Tissue Engineering, eds Van Bitterswijk et al, Academic Press Series in Biomedical Engineering, Elsevier, 2008 (ebook via Chalmers Library). Handouts of lecture notes and scientific articles.

Examination

Grades for the course will be based on article review sessions, the group project oral and written presentations, an individual grade from group members, and an oral final exam.


Page manager Published: Thu 04 Feb 2021.